Table 4.

Annualized percent change in pRNFL and GCIPL in healthy controls and MS by age at baseline

	Annualized Percent Change in pRNFL Thickness β (95% CI)		P-value*	Proportion of pRNFL thinning attributable to normal aging	Annualized Percent Change in GCIPL Thickness β (95% CI)		P-value*	Proportion of GCIPL thinning attributable to normal aging
Age at baseline (years)	HC	MS			HC	MS
25	−0.38% (−0.55% to −0.21%)	−0.89% (−1.04% to −0.75%)	<0.001	42.7%	−0.07% (−0.18% to 0.03%)	−0.42% (−0.54% to −0.31%)	<0.001	16.7%
35	−0.38% (−0.48% to −0.27%)	−0.78% (−0.87% to −0.68%)	<0.001	48.7%	−0.16% (−0.23% to −0.09%)	−0.45% (−0.52% to −0.37%)	<0.001	35.6%
45	−0.37% (−0.50% to −0.24%)	−0.66% (−0.73% to −0.59%)	<0.001	56.1%	−0.25% (−0.33% to −0.17%)	−0.48% (−0.53% to −0.43%)	<0.001	52.1%
55	−0.36% (−0.58% to −0.15%)	−0.54% (−0.63% to −0.46%)	0.13	66.7%	−0.34% (−0.47% to −0.21%)	−0.51% (−0.57% to −0.44%)	0.03	66.7%
65	−0.36% (−0.67% to −0.05%)	−0.43% (−0.56% to −0.29%)	0.70	83.7%	−0.43% (−0.62% to −0.24%)	−0.53% (−0.64% to −0.43%)	0.33	81.1%

^*P-value for comparison of point estimates of rates of change in retinal layer thicknesses between controls and MS participants at given age

HC: healthy controls; MS: multiple sclerosis; CI: confidence intervals; pRNFL: peri-papillary retinal nerve fiber layer; GCIPL: ganglion cell + inner plexiform layer; INL: inner nuclear layer; ONL: outer nuclear layer