Table 4.
Clinicopathological characteristics of desmoplastic patients only (i.e. 100% desmoplastic HGP) stratified by preoperative treatment status (combined cohort).
| Desmoplastic patients only | |||||
|---|---|---|---|---|---|
| Preoperative chemotherapy | |||||
| No | Yes | ||||
| Missing (%) | n = 145 (%) | n = 318 (%) | P value | ||
| Age at resection CRLM (median [IQR]) | 67.0 [56.0–75.0] | 61.0 [51.0–68.0] | <0.001 | ||
| Gender | Female | 87 (60) | 206 (65) | 0.322 | |
| Male | 58 (40) | 112 (35) | |||
| Primary tumour location | Right‐sided | 21 (5) | 31 (22) | 82 (27) | 0.560 |
| Left‐sided | 64 (46) | 129 (43) | |||
| Rectal | 44 (32) | 92 (30) | |||
| (y)pT‐stage | 0 | 31 (7) | 1 (1) | 15 (5) | <0.001 |
| 1 | 5 (4) | 2 (1) | |||
| 2 | 29 (20) | 25 (9) | |||
| 3 | 97 (68) | 190 (66) | |||
| 4 | 10 (7) | 58 (20) | |||
| (y)pN‐stage | 0 | 13 (3) | 84 (58) | 119 (39) | <0.001 |
| 1 | 46 (32) | 116 (38) | |||
| 2 | 14 (10) | 71 (23) | |||
| Disease‐free interval in months (median [IQR]) | 5 (1) | 9.0 [0.0–22.0] | 0.0 [0.0–1.0] | <0.001 | |
| Number of CRLM (median [IQR]) | 3 (1) | 1.0 [1.0–2.0] | 2.0 [1.0–4.0] | <0.001 | |
| Diameter of largest CRLM in cm (median [IQR]) | 15 (3) | 2.3 [1.5–3.5] | 1.8 [1.1–3.0] | 0.002 | |
| Preoperative CEA in μg/l (median [IQR]) | 37 (8) | 4.8 [2.6–11.5] | 8.0 [3.1–29.9] | <0.001 | |
| APC | Wildtype | 364 (79) | 3 (18) | 15 (18) | 0.950 |
| Mutant | 14 (82) | 67 (82) | |||
| KRAS | Wildtype | 256 (55) | 17 (52) | 94 (54) | 0.791 |
| Mutant | 16 (48) | 80 (46) | |||
| NRAS | Wildtype | 293 (63) | 25 (93) | 135 (94) | 0.713 |
| Mutant | 2 (7) | 8 (6) | |||
| BRAF | Wildtype | 277 (60) | 28 (97) | 149 (95) | 0.704 |
| Mutant | 1 (3) | 8 (5) | |||
| MSI status | MSS | 343 (74) | 27 (93) | 86 (95) | 0.779 |
| MSI | 2 (7) | 5 (5) | |||
MSS–microsatellite stable.