Table 2. Changes in Metabolic Parameters After Switching From Fenofibrate to Pemabibrate.
| Baseline | After 3 months | After 6 months | After 12 months | |
|---|---|---|---|---|
| Aspartate aminotransferase (IU/L) | 79.1 ± 194.1 | 63.6 ± 148.4 | 34.4 ± 35.7 | 26.7 ± 8.5 |
| Alanine aminotransferase (IU/L) | 37.4 ± 31.1 | 31.1 ± 20.9 | 27.8 ± 18.6* | 34.7 ± 27.1 |
| γ-glutamyl transpeptidase (IU/L) | 144.8 ± 319.8 | 83.4 ± 140.7 | 94.2 ± 160.9 | 92.0 ± 154.8 |
| Creatine phosphokinase (IU/L) | 100.1 ± 72.4 | 110.2 ± 64.2 | 100.6 ± 37.5 | 136.3 ± 139.5 |
| Plasma glucose (mg/dL) | 148.9 ± 42.9 | 164.6 ± 53.1 | 150.1 ± 34.4 | 162.5 ± 41.6 |
| HbA1c (%) | 7.0 ± 1.2 | 6.9 ± 0.9 | 6.8 ± 0.8 | 6.9 ± 0.8 |
| Total cholesterol (mg/dL) | 216.7 ± 70.3 | 201.4 ± 34.2 | 191.4 ± 15.4 | 186.1 ± 30.8 |
| Triglyceride (mg/dL) | 346.3 ± 468.5 | 314.3 ± 335.8 | 203.9 ± 105.4 | 217.5 ± 123.0 |
| HDL-cholesterol (mg/dL) | 55.5 ± 27.5 | 47.4 ± 10.1 | 47.8 ± 10.8 | 51.7 ± 11.9 |
| LDL-cholesterol (mg/dL) | 108.7 ± 18.5 | 112.0 ± 16.9 | 116.8 ± 15.4 | 108.4 ± 26.5 |
| Non-HDL-cholesterol (mg/dL) | 161.2 ± 72.9 | 154.0 ± 34.3 | 143.6 ± 10.7 | 134.4 ± 30.9 |
*P < 0.05 vs. baseline.