Table 3.

NPESS criteria for scoring of pancreatic endocrine cells

Degradation score	Nucleus	Mitochondria	ER dilation	Vacuolization	Cytoplasmic vesicle depletion
0	Normal appearance	Normal appearance	Absent	Absent	Absent
1	Chromatin condensation or loss (mild to moderate)	Open appearance	Mild dilation	Mild vacuolization(0%–25% of cell)	Mild vesicle loss (<25% of cell membrane)
2	Chromatin condensation or loss (moderate to severe)	Swollen appearance	Moderate dilation	Moderate vacuolization (25%–50% of cell)	Moderate vesicle loss (25%–50% of cell membrane)
3	Chromatin condensation and detachment from nuclear membrane	“Blown” mitochondria—disrupted cristae, loss of highly recognizable components	Severe dilation	Severe vacuolization (>50% of cell)	Severe vesicle loss (>50% of cell membrane)

ER, endoplasmic reticulum; NPESS, Newcastle Pancreas Endocrine Stress Score.