TABLE 4.
Distribution of Modifiable LekCheck Factors and Logistic Regression Analyses for Colorectal Anastomotic Leakage
| Univariate Analysis∗ | Multivariate Analysis† | ||||
| Variable | No. (%) | OR (95% CI) | P Value | OR (95% CI) | P Value |
| Temperature | |||||
| ≥ 36 ° | 1229 (80%) | 1 | 1 | ||
| < 36 ° | 306 (20%) | 1.78 (1.16–2.74) | 0.008 | 1.39 (0.85–2.29) | 0.186 |
| Glucose (mg/dL) | |||||
| ≤ 109.8 | 39 (27%) | 1 | 1 | ||
| > 109.8 | 1082 (73%) | 2.79 (1.53–5.07) | <0.001 | 2.8 (1.44–5.58) | 0.003 |
| Antibiotics prophylaxes | |||||
| 15–60 min | 1102 (73%) | 1 | 1 | ||
| < 15 or > 60 min | 399 (27%) | 2.08 (1.40–3.10) | <0.001 | 1.62 (1.03–2.55) | 0.037 |
| Administration of vasopressors | |||||
| No | 928 (62%) | 1 | 1 | ||
| Yes | 579 (38%) | 1.93 (1.30–2.87) | <0.001 | 1.8 (1.13–2.73) | 0.012 |
| Hemoglobin (g/dL) | |||||
| Male ≥ 10.5, female ≥ 9.7 | 1366 (94%) | 1 | 1 | ||
| Male < 10.5, female < 9.7 | 92 (6%) | 4.80 (2.80–8.23) | <0.001 | 5.4 (2.94–9.95) | <0.001 |
| Blood loss (mL) | |||||
| ≤ 100 | 1058 (69%) | 1 | |||
| > 100 | 484 (31%) | 1.06 (0.71–1.58) | 0.753 | ||
| Blood transfusion | |||||
| No | 1527 (98%) | 1 | |||
| Yes | 35 (2%) | 1.44 (0.23–2.78) | 0.745 | ||
| Oxygen saturation | |||||
| ≥ 95% | 1441 (94%) | 1 | |||
| < 95% | 86 (6%) | 1.24 (0.59–2.59) | 0.558 | ||
| Mean arterial pressure (mm Hg) | |||||
| ≥ 60 | 1496 (98%) | 1 | |||
| < 60 | 32 (2%) | 0.92 (0.21- 3.94) | 0.800 | ||
| Fluid administration (mL/h) | |||||
| ≤ 1000 | 936 (76%) | 1 | 1 | ||
| > 1000 | 303 (24%) | 0.56 (0.33–0.96) | 0.037 | 0.65 (0.34–1.24) | 0.191 |
| Fecal contamination | |||||
| No | 1407 (94%) | 1 | 1 | ||
| Yes | 89 (6%) | 4.04 (2.31–67.04) | <0.001 | 2.98 (1.55–5.75) | <0.001 |
| Epidural analgesia | |||||
| No | 1011 (67%) | 1 | 1 | ||
| Yes | 487 (33%) | 2.31 (1.56–3.40) | <0.001 | 1.81 (1.15–2.84) | 0.010 |
| Duration of surgery (h) | |||||
| ≤ 3 | 1052 (70%) | 1 | 1 | ||
| > 3 | 446 (30%) | 2.19 (1.48–3.24) | 0.000 | 1.86 (1.18–2.95) | 0.007 |
| Intraoperative event∗ | |||||
| No | 1344 (86%) | 1 | 1 | ||
| Yes | 218 (14%) | 1.94 (1.23–3.05) | 0.004 | 1.15 (0.66–1.99) | 0.622 |
∗
Adjusted for: sex, American Society of Anesthesia score (ASA) ≥ 3, diabetes, pack years ≥ 15, distance of tumor from anal verge <15 cm, and anastomotic location.
†
Adjusted for: sex, American Society of Anesthesia score (ASA) ≥ 3, diabetes, pack years ≥ 15, distance of tumor from anal verge <15 cm, anastomotic location and configuration, stoma type and surgical approach.
Bold values have been found statistically significant (P < 0.05).