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. 2021 Dec 18;30(1):69–82.e10. doi: 10.1016/j.chom.2021.12.010

Figure 4.

Figure 4

Broadly neutralizing next-generation SARS-CoV-2 bNAbs

(A) Neutralization escape map profile of n = 57 elite neutralizer NAbs against 25 SARS-CoV-2 spike pseudovirus variants. Average IC50 values, relative neutralization breadth across the variants, the spike epitope determined by ELISA, and cross-neutralizing capacity, as well as IGHV3-53 usage, are depicted in columns to the right.

(B) Dot plot depicting average IC50s and IC50s against Wu01 for all isolated bNAbs (n = 23) with the IGHV3-53/IGKV1-9 bNAbs highlighted in blue. Pie chart shows fraction of IGHV3-53/IGKV1-9 bNAbs among nBAns obtained from elite neutralizers.

(C) Plot evaluating the IC50 values of the broadest (100%) and most potent NAbs against SARS-CoV-2 pseudovirus variants with spike sequence of B.1, B.1.1.7, B.1.351, B.1.429, B.1.617, and B.1.617.2 are compared to published monoclonal antibodies. REGN antibodies tested up to 5 μg/mL. Gray area in (C) highlights values below 0.02 μg/mL, and black bars denote geometric means.