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. 2021 Nov 22;23(12):1287–1298. doi: 10.1038/s41556-021-00792-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, Representative images of RNAPI foci (RPA194) showing the levels of global transcription (EU pulse labelling) in normal (1BR) and patient-derived fibroblasts with XRCC1 mutations (XD1) following mock treatment or at the indicated times after treatment with 60 μM H₂O₂ for 5 min. The cells were pulse labelled with EU as in Fig. 1. b, Levels of global transcription (EU immunofluorescence) from the experiment shown in a. Data are the mean ± s.e.m. of three independent experiments. Statistical significance was determined using a two-way ANOVA with Sidak’s multiple comparisons test (significantly different P values are indicated). c, Representative images of the global transcription levels (EU immunofluorescence) in WT and Xrcc1^Nes-cre mouse cerebellar neurons (NeuN), pretreated with PARPi, following mock treatment or at the indicated times after treatment with 250 μM H₂O₂ for 5 min. Representative images from one of three independent experiments are shown. Scale bars, 10 μm.

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