Box 1.
Consensus definition of late presentation with chronic viral hepatitis for medical care.
| Presentation with advanced liver disease (ALD) in untreated patients with chronic hepatitis B and C | A patient with chronic HBV or HCV and significant fibrosis assessed by one of the following: serologic fibrosis score ≥ 3 (assessed by APRI score > 1.5, FIB-4 > 3.25, Fibrotest > 0.59 or alternatively transient elastography (FibroScan) > 9.5 kPa or liver biopsy (≥ METAVIR stage F3) in patients with no previous antiviral treatment |
| Presentation with late-stage liver disease (LSLD) in untreated patients with chronic hepatitis B and C | A patient with a fibrosis score > F3 and presence of at least one symptom of decompensated cirrhosis (jaundice, hepatic encephalopathy, clinically detectable ascites, variceal bleeding) and/or hepatocellular carcinoma in patients with no previous antiviral treatment |
Source Mauss et al.15.
APRI aspartate aminotransferase to platelet ratio, F3 stage 3 fibrosis, FIB-4 Fibrosis 4, HBV hepatitis B virus, HCV hepatitis C virus, METAVIR Meta-analysis of Histological Data in Viral Hepatitis.