Table 1.

High risk nsSNPs identified in MYB family genes by in silico tools.

SNP ID	AA change	PROVEAN		SIFT		PolyPhen-2		SNPs&GO		PhD-SNP
		Preda	Sc	Predb	Sc	Effectc	Sc	Predd	RI	Prede	RI
MYB
rs1302072057	R73L	Del	− 3.80	Dmg	0	Pro.dmg	1	Disease	4	Disease	7
rs1302072057	R73Q	Del	− 6.65	Dmg	0	Pro.dmg	1	Disease	5	Disease	8
rs866246271	C78Y	Del	− 10.45	Dmg	0	Pro.dmg	0.999	Disease	7	Disease	9
rs1246761830	K84E	Del	− 3.80	Dmg	0.001	Pro.dmg	0.998	Disease	5	Disease	4
rs1231582413	P94R	Del	− 8.55	Dmg	0.001	Pos.dmg	0.608	Disease	3	Disease	1
rs1776412940	W95L	Del	− 12.35	Dmg	0	Pro.dmg	1	Disease	4	Disease	7
rs1361650612	G111S	Del	− 5.69	Dmg	0	Pro.dmg	1	Disease	5	Disease	7
rs1316378738	A158E	Del	− 4.74	Dmg	0	Pos.dmg	0.577	Disease	7	Disease	6
rs1583273308	R176Q	Del	− 3.80	Dmg	0	Pro.dmg	1	Disease	6	Disease	8
rs1179275735	N183S	Del	− 4.58	Dmg	0	Pro.dmg	1	Disease	7	Disease	5
rs1335964521	R191Q	Del	− 3.75	Dmg	0	Pro.dmg	1	Disease	2	Disease	5
rs1444007668	K192E	Del	− 3.75	Dmg	0	Pro.dmg	0.999	Disease	7	Disease	6
rs1777011832	D286Y	Del	− 6.18	Dmg	0	Pro.dmg	1	Disease	4	Disease	7
rs1247338239	W406C	Del	− 5.30	Dmg	0.001	Pro.dmg	0.985	Disease	0	Disease	5
rs1247579811	P574S	Del	− 6.02	Dmg	0	Pro.dmg	1	Disease	0	Disease	5
rs775717051	A594P	Del	− 3.37	Dmg	0.001	Pro.dmg	1	Disease	1	Disease	6
rs756830286	G603S	Del	− 4.53	Dmg	0.007	Pro.dmg	1	Disease	0	Disease	5
MYBL1
rs1367098628	R68C	Del	− 7.60	Dmg	0	Pro.dmg	1	Disease	3	Disease	7
rs767355502	R68H	Del	− 4.75	Dmg	0	Pro.dmg	0.996	Disease	1	Disease	6
rs1472109411	P83T	Del	− 7.60	Dmg	0	Pos.dmg	0.811	Disease	3	Disease	3
rs766676175	G122S	Del	− 5.69	Dmg	0.002	Pro.dmg	0.975	Disease	3	Disease	5
rs768073245	R156W	Del	− 6.55	Dmg	0.002	Pro.dmg	1	Disease	2	Disease	5
rs1299187617	R160H	Del	− 4.74	Dmg	0	Pro.dmg	0.990	Disease	2	Disease	5
rs866260709	S175Y	Del	− 3.62	Dmg	0	Pro.dmg	1	Disease	0	Disease	2
rs1281804000	R185Q	Del	− 3.30	Dmg	0.003	Pro.dmg	0.978	Disease	0	Disease	3
rs1809689475	E265K	Del	− 3.34	Dmg	0.005	Pro.dmg	0.957	Disease	2	Disease	6
rs1225867137	M276T	Del	− 4.79	Dmg	0.006	Pro.dmg	0.992	Disease	2	Disease	6
rs1808814297	P512R	Del	− 6.44	Dmg	0	Pro.dmg	1	Disease	1	Disease	6
rs1361362325	C514W	Del	− 5.98	Dmg	0.002	Pro.dmg	1	Disease	1	Disease	6
rs770108773	A562E	Del	− 3.54	Dmg	0.001	Pro.dmg	1	Disease	0	Disease	6
rs777095803	A565P	Del	− 2.90	Dmg	0.003	Pro.dmg	1	Disease	1	Disease	7
rs777150665	G596R	Del	− 3.07	Dmg	0.001	Pro.dmg	1	Disease	0	Disease	5
rs1281394929	G721E	Del	− 5.73	Dmg	0.007	Pro.dmg	1	Disease	5	Disease	6
MYBL2
rs748449655	L57R	Del	− 4.37	Dmg	0.001	Pro.dmg	0.999	Disease	8	Disease	2
rs1228232756	R64C	Del	− 6.64	Dmg	0	Pro.dmg	1	Disease	8	Disease	5
rs867195152	G102D	Del	− 6.10	Dmg	0	Pro.dmg	0.995	Disease	8	Disease	6
rs1164247754	R116Q	Del	− 3.35	Dmg	0.022	Pro.dmg	1	Disease	8	Disease	6
rs1323182096	R124C	Del	− 7.06	Dmg	0	Pro.dmg	1	Disease	8	Disease	7
rs1300383239	N127D	Del	− 4.52	Dmg	0.006	Pro.dmg	0.971	Disease	2	Disease	4
rs1295676923	G166V	Del	− 8.00	Dmg	0	Pos.dmg	0.946	Disease	8	Disease	7
rs968286439	R167K	Del	− 2.63	Dmg	0	Pro.dmg	0.999	Disease	7	Disease	5
rs1271670254	D169G	Del	− 5.87	Dmg	0	Pro.dmg	1	Disease	7	Disease	7
rs1438994955	S178C	Del	− 4.01	Dmg	0	Pro.dmg	1	Disease	3	Disease	3
rs781229138	G188C	Del	− 6.21	Dmg	0.003	Pro.dmg	0.966	Disease	6	Disease	5
rs1171631148	E552V	Del	− 5.52	Dmg	0.001	Pro.dmg	1	Disease	7	Disease	2
rs776972688	G530R	Del	− 5.97	Dmg	0.001	Pro.dmg	1	Disease	7	Disease	2
rs779332836	G669R	Del	− 6.13	Dmg	0	Pro.dmg	1	Disease	6	Disease	3
rs776117094	R682W	Del	− 5.78	Dmg	0	Pro.dmg	1	Disease	5	Disease	1

AA amino acid, Pred prediction, TI tolerance index, Sc score, Del deleterious, Dmg damaging, Pro.dmg probably damaging, Pos.dmg possibly damaging, RI reliability index.

^aPROVEAN: Del (Sc < − 2.5).

^bSIFT: Dmg (Sc ≤ 0.05).

^cPolyPhen-2: Pos.dmg (0.453 ≤ Sc ≤ 0.956), Pro.dmg (0.957 ≤ Sc ≤ 1.0).

^dSNPs&GO: Disease (Probability > 0.5).

^ePhD-SNP: Disease (Probability > 0.5).