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. 2021 Dec 17;11:24192. doi: 10.1038/s41598-021-03680-3

Table 7.

Grading of Recommendations Assessment, Development, and Evaluation (GRADE) summary of findings table for the outcomes of the systematic review and meta-analysis.

Quality assessment Summary of results Importance
N Study Design Methodological Limitations Inconsistency Indirectness Imprecision Other considerations Number of participants Effect General quality
Accuracy (95% CI)
Is cheilososcopy a reliable method for estimating sex?
7 Diagnostic accuracy studies Not seriousa Seriousb Not seriousc Seriousd none 1547 76.76 (65.81–87.70) ⨁⨁ LOW Critical

GRADE Working Group grades of evidence.

High certainty: We are very confident that the true effect lies close to that of the estimate of the effect.

Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.

Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect.

Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect.

aMajority of the studies presented low risk of bias; b The heterogeneity (I2) was high (> 75%) and no overlapping of effect estimates; c Evidence stems from an adequate population; d Wide credible confidence interval.