Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 17;13(1):4. doi: 10.1038/s41419-021-04174-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — A The downstream genes of transcription factor c-MYC predicted by hTFtarget and intersected with 45 obviously upregulated genes to obtain 12 genes. B Clinical data of TCGA analyzed by GEPIA to draw the survival curve between SULT2B1 expression and colon cancer. C The protein expression of c-MYC in colon cancer and adjacent normal tissues detected by immunohistochemistry (adjacent tissues: n = 120; tumor tissues: n = 120; ×200). D The mRNA expression of c-MYC and SULT2B1 in colon cancer cells after overexpression and knocking down c-MYC determined by RT-qPCR. E Detection of ECAR in colon cancer cells after knocking down c-MYC. F Detection of glucose content in colon cancer cells after knocking down c-MYC. G Detection of lactate production in colon cancer cells after knocking down c-MYC. H Detection of ATP/ADP in colon cancer cells after knocking down c-MYC. I RT-qPCR to detect the mRNA expression of GLUT1 and LDHA in colon cancer cells after knocking down c-MYC. The cell experiment was repeated three times. *p < 0.05 between two groups.