TABLE 2.

Functions of biological metabolism in cancer progression

Name	PMID	Function in cancer	Enrichment phenotype
Glycolysis	31629815 30822194	1. Fulfill the biosynthetic requirements of tumor cell proliferation. 2. Enhance cell resistance to antitumor therapies through accumulation of lactate.	NS
Nucleotide metabolism	24486217	1. Provide a high level of dNTPs pool for DNA replication and repair. 2. Increase genomic instability to induce cancer initiation.	High
Fatty acid metabolism	31819192	1. Provide structural components of the membrane matrix. 2. Serve as secondary messengers and fuel sources. 3. Promote cancer progression through remodeling TIM.	High
Glutamate and glutamine metabolism	23999442	Involve in energy formation, redox homeostasis, macromolecular synthesis, and signaling in cancer cells.	NS
Glycine serine and threonine metabolism	24657017	Provide the essential precursors for the synthesis of proteins, nucleic acids, and lipids.	High

Abbreviations: NS, Not significant; TIM, tumor immune microenvironment. High, high SLC7A11 expression group.