TABLE 3.
Metabolic reprogramming caused by SLC7A11
| Gene set | Enrichment score (ES) | Normalized (NES) |
Nominal p value |
|---|---|---|---|
| Glycolysis metabolism | |||
| GO glycolytic process | 0.294 | 1.063 | 0.377 |
| Hallmark glycolysis | 0.267 | 0.946 | 0.507 |
| Glycolysis (module 306) | −0.615 | −1.486 | 0.142 |
| Reactome glycolysis | 0.311 | 0.961 | 0.477 |
| Biosynthetic metabolisms | |||
| Nucleotide metabolism (module 337) | 0.619 | 1.952 | 0.009 |
| Hallmark fatty acid metabolism | 0.505 | 1.657 | 0.049 |
| Reactome glutamate and glutamine metabolism | 0.469 | 1.206 | 0.277 |
| KEGG glycine serine and threonine metabolism | 0.591 | 1.739 | 0.036 |
| Ferroptosis process | |||
| WP ferroptosis | −0.617 | −1.846 | 0.012 |
| Hallmark oxidative phosphorylation | −0.586 | −1.538 | 0.135 |
| Hallmark reactive oxygen species pathway | −0.324 | −0.956 | 0.522 |
| GOBP iron ion transport | 0.357 | 1.293 | 0.202 |
Abbreviations: BP, biological process; GO, Gene Ontology; GSEA, Gene set enrichment analysis; KEGG, Kyoto Encyclopedia of Genes and Genomes; WP, Wikipedia.