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The biogenesis of circRNAs. (A) Intron pairing‐driven circularization. The reverse complementary sequences on both sides of the paired introns mediate reverse splicing to generate circRNAs. (B) RBPs bind to the flanks of introns to bring the donor site closer to the acceptor site, thereby assisting circulation. (C) The biogenesis of CiRNAs require a consensus motif. (D) Alternative back‐splicing
