FIGURE 2.

Network structure for all the included trials. Network structure according to (A) treatment modes and (B) treatment regimens. Each circular node represents a treatment type (dark blue represents the main object for analysis of study and light blue represents the object that is only used for transmission and not for main analysis). The circle size is proportional to the total number of patients. The width of solid lines is proportional to the number of studies performing head‐to‐head comparisons in the same study. The dotted lines represent indirect comparisons. Anti‐angio + Chemo, Anti‐angiogenic therapy + Chemotherapy; Chemo, Chemotherapy; IO + Anti‐angio + Chemo, Immunotherapy + Anti‐angiogenic therapy + Chemotherapy; IO + Chemo, Immunotherapy + Chemotherapy; IO + IO, Immunotherapy + Immunotherapy; IO + IO + Chemo, Immunotherapy + Immunotherapy + Chemotherapy