TABLE 1.
Baseline of renal AEs for ICIs and control group in FAERS database
| Character | Renal AEs in any other drugs (1104288) | Renal AEs in ICIs (4578) |
|---|---|---|
| Gender | ||
| Male | 350457(31.74) | 2530(55.26) |
| Female | 462724(41.90) | 1434(31.32) |
| Missing | 291107(26.36) | 614(13.41) |
| Age | ||
| <65 | 309844 (28.06) | 1493 (32.61) |
| >=65 | 352760 (31.94) | 1956 (42.73) |
| Missing | 441684 (40.00) | 1129 (24.66) |
| Year | ||
| 2014 | 51463 (4.66) | 44 (0.96) |
| 2015 | 105145 (9.52) | 18 (0.39) |
| 2016 | 162576 (14.72) | 669 (14.61) |
| 2017 | 161853 (14.66) | 901 (19.68) |
| 2018 | 385852 (34.94) | 1773 (38.73) |
| 2019 Q1‐Q2 | 237399 (21.50) | 1173 (25.62) |
| Outcome | ||
| Death | 96432(8.73) | 847(18.50) |
| Life‐threatening | 34753(3.15) | 216(4.72) |
| Disability | 23340(2.11) | 51(1.11) |
| Hospitalization | 332388(30.10) | 1748(38.18) |
| Congenital anomaly | 1095(0.10) | 2(0.04) |
| Other serious (important medical events) | 447951(40.56) | 1119(24.44) |
| Required intervention to prevent permanent impairment/damage | 335(0.03) | 1(0.02) |
| Missing | 167994(15.21) | 594(12.98) |
| Report countries | ||
| United States | 702909(63.65) | 1587(34.67) |
| Japan | 49446(4.48) | 835(18.24) |
| France | 45733(4.14) | 428(9.35) |
| Germany | 30079(2.72) | 280(6.12) |
| Italy | 16263(1.47) | 135(2.95) |
| Great Britain | 47726(4.32) | 133(2.91) |
| Canada | 35314(3.20) | 106(2.32) |
| Spain | 11241(1.02) | 105(2.29) |
| Australia | 6876(0.62) | 88(1.92) |
| Netherlands | 6176(0.56) | 57(1.25) |
| Others | 118406(10.72) | 591(12.91) |
| Missing | 34119(3.09) | 233(5.09) |