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. 2021 Dec 1;25(1):103535. doi: 10.1016/j.isci.2021.103535

Figure 2.

Figure 2

ReCORM increases HO-1 and NRF-1 proteins and decreases pro-fibrotic proteins

(A–D) C57BL/6 mice were injected with 3 consecutive doses of 1 mg/kg ReCORM or iCORM. Seven days post-BLM with or without ReCORM, lungs were excised and analyzed for HO-1, NRF-1, Nrf2, and PGC-1α protein expression measured by immunoblotting, with tubulin protein as internal standard (A-D).

(E) Immunoblots show lung TGFβ1 protein levels on day 7 post-BLM, which are reduced by ReCORM.

(F) Scatterplots of TGFβ1 densitometry levels.

(G) Immunoblot of TGFβR1 protein levels on day 7 post BLM; ReCORM reduces the receptor levels in the lung.

(H) Scatterplots of TGFβR1 densitometry levels. Experiments done in triplicate (n = 6/group); representative data shown). Semi-quantitative group data are expressed as mean ± SD.∗P < 0.05 compared ReCORM with the iCORM group. †P < 0.05 ReCORM + BLM vs BLM group).