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. 2021 Dec 1;25(1):103535. doi: 10.1016/j.isci.2021.103535

Figure 3.

Figure 3

Pro-fibrotic and anti-fibrotic response in lungs of BLM treated mice

(A) Immunoblot of lung extracellular fibrosis proteins Fn1 and Vim and epithelial marker E-cad during BLM-induced lung fibrosis.

(B–D) Scatterplots of densitometry analysis of Fn1, Vim, and E-cad at 7 d post-BLM.

(E) Immunoblot of lung nuclear proteins CCN5, Smad7, and phosphorylated Smad2 and 3 as targets for Smad7 during BLM-induced lung fibrosis.

(F–I) Scatterplots of densitometry analysis of CCN5, pSmad2, pSmad3, and Smad7 at 7 d. N = 6 in each group and data expressed as mean ± SD. ∗P < 0.05 compared with the ReCORM and iCORM group, †P < 0.05 ReCORM + BLM vs BLM group.