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. 2021 Dec 1;25(1):103535. doi: 10.1016/j.isci.2021.103535

Figure 9.

Figure 9

ReCORM fails to induce anti-fibrotic response in lung of BLM treated HO-1CKO mice

(A) Lung section images from four groups of mice compared by Masson's trichrome staining for collagen (4x: scale bars 4 μM).

(B) Optical density changes in collagen-stained lung using NIS-Elements imaging software 5.2 (Nikon). The HO-1CKO mice were euthanized at 7 d post BLM with and without ReCORM and the lungs were homogenized for extracting Lung proteins and analyzed for fibrogenic proteins α-SMA, Col1a1, pSmad2, pSmad3, and TGFβ1 and the antifibrogenic proteins NRF-1 and Smad7.

(C–I) Scatterplots of densitometry analysis of lung proteins. N = 5 in each group. Quantitative data are expressed as mean ± SD. ∗p < 0.05 compared ReCORM with the iCORM injected group, †p < 0.05 ReCORM + BLM vs BLM groups.