Table 3.
[35S]-GTPγS Binding Assays of Selected and Reference Compounds for Efficacy at the hCB2 Cannabinoid Receptors
| compound | [35S]-GTPγS specific binding (control = 100%)a |
|---|---|
| CP-55,950 | 131 ± 6** |
| AM-630 | 67 ± 4** |
| GBD-002 (3) | 134 ± 5* |
| GBD-003 (4) | 108 ± 9 |
| GBD-005 (26) | 99 ± 3 |
| GBD-006 (27) | 102 ± 4 |
| GBD-007 (28) | 102 ± 9 |
| GBD-009 (30) | 87 ± 8 |
| GBD-010 (31) | 90 ± 3 |
| GBD-011 (32) | 81 ± 2** |
| GBD-012 (33) | 106 ± 7 |
| GBD-013 (34) | 92 ± 2* |
| GBD-014 (35) | 96 ± 5 |
| GBD-029 (49) | 121 ± 8 |
a
The results are expressed as the percentages of stimulation of [35S]-GTPγS binding (the basal value set at 100%) obtained for a concentration of ligands of 10 μM. Data are the mean ± standard error of the mean of three experiments. Statistical significance from 100% (basal) as assessed by one-sample t-test
*
P < 0.05
**
P < 0.01.