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In vitro regression parameters.
| Bottom (×10−6 cm/s) | Top (×10−6 cm/s) | IC50 (nM) |
Hill Slope | R2 | |
|---|---|---|---|---|---|
| B-A | 1.35 ± 0.02 | 7.16 ± 0.65 | 5.80 ± 1.70 | −1.04 ± 0.24 | 0.959 |
| A-B | 0.498 ± 0.110 | 1.91 ± 0.14 | 9.50 ± 5.61 | 0.615 ± 0.199 | 0.847 |
Obtained regression parameters (Eq. 1) of etoposide Papp against the zosuquidar concentration in the basolateral(B)-apical(A) direction (n = 4) and in the A-B direction (n = 3).
