Figure 7.
Hyperglycaemia-induced arrhythmogenic action potential changes are exacerbated in heart failure. (A) High glucose (30 mM, 6 min) further prolonged action potential duration (APD) in heart failure (HF) vs. age-matched (AM) control. (B) AP duration at 90% repolarization (APD90) and short-term variability (STV) of APD90. (AM control: n = 8 cells from three animals; HF: n = 8 cells from three animals.) Nested t-test; NS, non-significant; *P < 0.05 vs. 5.5 mM glucose; #P < 0.05 vs. AM control.