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. 2021 Nov 15;298(1):101403. doi: 10.1016/j.jbc.2021.101403

Figure 2.

Figure 2

Amino acid sequence alignment of different DARPin N-Caps. Amino acids in N02, N03, and N04 that are identical to the one present in N01 are indicated as dots. The sequence numbering is shown as used in the text. N01, the original N-Cap, as described by Binz et al. (2). N02, an improved N-Cap, as described in WO′655 and present in the two anti-HSA DARPin domains of ensovibep (10). N03, an N-Cap where 12 out of the 32 amino acids are changed in comparison to N01. N04, the N-Cap of the DARPin domain of abicipar pegol (28). DARPin, designed ankyrin repeat protein; HSA, human serum albumin.