Table 3. Pooled estimate, publication bias and heterogeneity test in overall and subgroup .
| Variable |
Number of studies |
Pooled estimation (95 % CI) |
Heterogeneity test |
Publication bias value | |
| I2 (%) | Τ2 | ||||
|
Fever Mean age>49 Mean age <=49 |
55 |
0.78 (0.74- 0.82) 0.81 (0.75- 0.85) 0.76 (0.69- 0.82) |
97.89 0.0 |
0.02 | 0.146 |
|
Cough Mean age>49 Mean age <=49 |
51 |
0.60 (0.57- 0.63) 0.60 (0.55- 0.65) 0.60 (0.55- 0.64) |
91.53 0.0 |
0.01 | < 0.001 |
|
Diarrhea Mean age>49 Mean age <=49 |
44 |
0.09 (0.07- 0.11) 0.08 (0.06- 0.12) 0.10 (0.06- 0.14) |
95.29 0.0 |
0.01 | 0.98 |
|
Fatigue Mean age>49 Mean age <=49 |
36 |
0.31 (0.26- 0.36) 0.40 (0.30- 0.50) 0.25 (0.20- 0.31) |
97.64 0.0 |
0.02 | 0.48 |
|
Headache Mean age>49 Mean age <=49 |
35 |
0.12 (0.10- 0.15) 0.11 (0.07- 0.15) 0.13 (0.10- 0.17) |
90.31 0.0 |
0.00 | < 0.001 |
| Lymphocyte | 39 | 1.13 (0.95- 1.31) | 0.0 | 0.00 | 0.26 |
|
CRP Mean age>49 Mean age <=49 |
32 |
18.73 (12.63- 24.84) 26.58 (16.38- 36.79) 13.85 (6.26- 21.45) |
85.2 0.0 |
150.50 | 0.4 |
| Platelet count | 31 | 180.85 (161.20- 200.50) | 0.0 | 0.00 | 0.17 |
| ALT | 31 | 26.69 (19.62- 33.77) | 0.0 | 0.00 | 0.06 |
| AST | 30 | 28.25 (22.77- 33.74) | 30.4 | 11.56 | 0.15 |
| Creatinine | 28 | 68.89 (62.28- 75.50) | 0.0 | 0.00 | 0.01 |
| Neutrophils | 28 | 3.52 (2.86- 4.19) | 0.0 | 0.00 | 0.001 |
| WBC | 28 | 5.72 (4.92- 6.52) | 2.9 | 0.03 | 0.06 |
|
Bilateral Pneumonia Mean age>49 Mean age <=49 |
29 |
0.64 (0.56- 0.72) 0.74 (0.64- 0.83) 0.55 (0.47- 0.62) |
99.46 0.0 |
0.02 | 0.24 |
|
GGO Mean age>49 Mean age <=49 |
23 |
0.60 (0.48- 0.72) 0.63 (0.44- 0.81) 0.57 (0.42- 0.71) |
99.66 0.0 |
0.12 | 0.74 |
|
Unilateral Pneumonia Mean age>49 Mean age <=49 |
12 |
0.24 (0.17- 0.31) 0.31 (0.07- 0.62) 0.21 (0.18- 0.23) |
93.47 0.0 |
0.01 | 0.42 |
|
Consolidation Mean age>49 Mean age <=49 |
12 |
0.31 (0.18- 0.46) 0.32 (0.19- 0.45) 0.31 (0.10- 0.57) |
94.67 0.0 |
0.03 | 0.18 |
* CRP, C creative protein; ALT, Alanine aminotransferase; AST, Aspartate aminotransferase; WBC, white blood cells; GGO Ground Glass Opacity, pooled estimation for (lymphocyte, CRP, platelet count, ALT, AST, creatinine, neutrophils and WBC) is weighted mean and prevalence for other variables