TABLE 1.
Water and food intake, plasma glucose levels, and biochemical parameters in adenine‐induced renal failure model
|
Control (n = 6) |
RF (n = 5) |
RF + S (n = 5) |
|
|---|---|---|---|
| Na (mmol/L) | 147.5 ± 0.8 | 145.4 ± 1.1 | 145.6 ± 0.5 |
| K (mmol/L) | 5.2 ± 0.2 | 5.1 ± 0.3 | 5.2 ± 0.3 |
| Cl (mmol/L) | 109.7 ± 0.4 | 108.6 ± 0.9 | 108.8 ± 1.0 |
| tCO2 (mmol/L) | 23.0 ± 0.5 | 23.4 ± 0.9 | 23.6 ± 0.2 |
| Hb (mg/dL) | 15.7 ± 0.2*** | 10.2 ± 0.2 | 11.2 ± 0.3* |
| Hct (%PCV) | 46.2 ± 0.7*** | 30.0 ± 0.6 | 33.0 ± 0.8* |
| AnGap (%PCV) | 21.0 ± 0.6 | 19.2 ± 0.9 | 19.0 ± 0.8 |
Body weight, food intake, water intake, and biochemical parameters (Na, K, Cl, tCO2, total carbon dioxide; Ht, hematocrit; and Hb, hemoglobin) were measured. Statistical analysis was performed using a Dunnett's test compared with the RF group. *p < 0.05 and ***p < 0.01 were treated as statistically significant. RF; renal failure, RF + S; and renal failure + SGL5213 (10 mg/kg).
Mean ± SEM, n = 5–6, *p < 0.05, ***p < 0.001 versus RF (Dunnett test).