Table 3. Seizure Burden and Anticonvulsant Use by Randomized Group.
| No. (%) | IRR (95% CI) | HIE subgroup, IRR (95% CI) | ||
|---|---|---|---|---|
| ESG | CSG | |||
| Electrographic seizures present | 69 (86) | 78 (83) | OR, 1.28 (0.56 to 2.97) | OR, 1.68 (0.61 to 4.61) |
| Total seizure burden in total aEEG recording, median (IQR), s | 848 (143 to 4840) | 613 (60 to 3030) | 1.61 (0.82 to 3.12) | 1.12 (0.60 to 2.11) |
| Seizure burden, mean (SD), s | ||||
| Per day of total aEEG recording | 325 (83 to 1355) | 285 (86 to 1734) | 1.19 (0.62 to 2.27) | 0.85 (0.44 to 1.64) |
| From 12 to 72 h from birth | 1063 (130 to 3725) | 535 (90 to 3710) | 0.91 (0.39 to 2.11) | 0.63 (0.27 to 1.44) |
| Total phenobarbital dose, mean diff (95% CI), mg/kg | NA | NA | 2.56 (−4.12 to 9.25) | 5.31 (−3.67 to 14.3) |
| No. | 69 | 64 | NA | NA |
| Mean (SD) | 38.2 (19.7) | 34.6 (20.5) | NA | NA |
| Total phenytoin dose, mean difference (95% CI), mg/kg | NA | NA | −6.15 (−15.68 to 3.37) | −10.9 (−27.60 to 5.82) |
| No. | 24 | 12 | NA | NA |
| Mean (SD) | 20.3 (10.0) | 27.7 (20.7) | NA | NA |
| Medications administered, No. | NA | NA | ||
| 1 | 43 | 49 | NA | NA |
| 2 | 10 | 6 | NA | NA |
| 3 | 12 | 7 | NA | NA |
| ≥4 | 4 | 3 | NA | NA |
Abbreviations: aEEG, amplitude integrated electroencephalography; CSG, clinical seizure group; ESG, electrographic seizure group; HIE, hypoxic-ischemic encephalopathy; IRR, incident rate ratio; NA, not applicable; OR, odds ratio.