Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 18;9:75. doi: 10.1186/s40560-021-00589-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 4 — Subgroup analysis, sensitivity analysis and TSA of the primary outcome. Legends: a Forest plots of the subgroup analysis for the change in SOFA score over the first 72 h. Septic shock was assessed as a subgroup. b Forest plots of the sensitivity analysis for the change in SOFA score over the first 72 h. Trials that excluded patients with renal failure at enrollment was assessed. c Trial sequential analysis for the change in SOFA score over the first 72 h. The blue cumulative z curve crossed the conventional monitoring boundary and the red trial sequential boundary for benefit (the pooled effect, 0.56; 95% CI 0.23–0.89; I² = 0%). The required information size (RIS) was 1038 (a two-sided a of 0.05, β of 80%)