Table 1.
Combination index and drug interaction in A549 cell line
| Combination | IC50 of drug in combination (Mean ± SD) |
Combination index at ED (Mean ± SD) |
Drug interaction |
|---|---|---|---|
| Fucoxanthin and cisplatin Combo 1 | 21.961 ± 1.929 | ED50: 0.178 ± 0.032 | Strong synergism |
| ED75: 0.084 ± 0.020 | Very strong synergism | ||
| ED90: 0.043 ± 0.021 | Very strong synergism | ||
| ED95: 0.029 ± 0.020 | Very strong synergism | ||
| Fucoxanthin and cisplatin Combo 2 | 19.382 ± 2.987 | ED50: 0.186 ± 0.032 | Strong synergism |
| ED75: 0.082 ± 0.005 | Very strong synergism | ||
| ED90: 0.038 ± 0.004 | Very strong synergism | ||
| ED95: 0.023 ± 0.004 | Very strong synergism | ||
| Fucoxanthin and cisplatin Combo 3 | 5.478 ± 0.532 | ED50: 0.188 ± 0.042 | Strong synergism |
| ED75: 0.097 ± 0.019 | Very strong synergism | ||
| ED90: 0.050 ± 0.011 | Very strong synergism | ||
| ED95: 0.033 ± 0.008 | Very strong synergism | ||
| Bixin and cisplatin Combo 1 | 25.219 ± 1.070 | ED50: 0.165 ± 0.023 | Strong synergism |
| ED75: 0.077 ± 0.019 | Very strong synergism | ||
| ED90: 0.038 ± 0.014 | Very strong synergism | ||
| ED95: 0.024 ± 0.011 | Very strong synergism | ||
| Bixin and cisplatin Combo 2 | 30.316 ± 1.859 | ED50: 0.196 ± 0.039 | Strong synergism |
| ED75: 0.094 ± 0.022 | Very strong synergism | ||
| ED90: 0.047 ± 0.014 | Very strong synergism | ||
| ED95: 0.030 ± 0.010 | Very strong synergism | ||
| Bixin and cisplatin Combo 3 | 21.330 ± 1.153 | ED50: 0.132 ± 0.037 | Strong synergism |
| ED75: 0.074 ± 0.025 | Very strong synergism | ||
| ED90: 0.029 ± 0.013 | Very strong synergism | ||
| ED95: 0.033 ± 0.008 | Very strong synergism |