Table 3.
Top 5 most significant and SETX function-related Gene Ontology (GO) categories for ALS4 disease-associated WGCNA modules
| Module name | Gene ontology category |
|---|---|
| ALS4MmMod02 overall | 1. GO:0099536 ~ synaptic signaling |
| 2. GO:0007399 ~ nervous system development | |
| 3. GO:0031223 ~ auditory behavior | |
| 4. GO:0046903 ~ secretion | |
| 5. GO:0032990 ~ cell part morphogenesis | |
| ALS4MmMod02 SETX function | 1. GO:0007218 ~ neuropeptide signaling pathway |
| 2. GO:0006915 ~ apoptotic process | |
| 3. GO:0051254 ~ positive regulation of RNA metabolic process | |
| 4. GO:0010628 ~ positive regulation of gene expression | |
| 5. GO:0006259 ~ DNA metabolic process | |
| ALS4MmMod32 overall | 1. GO:0021536 ~ diencephalon development |
| 2. GO:0051271 ~ negative regulation of cellular component movement | |
| 3. GO:0007159 ~ leukocyte cell–cell adhesion | |
| 4. GO:0022409 ~ positive regulation of cell–cell adhesion | |
| 5 GO:0010604 ~ positive regulation of macromolecule metabolic process | |
| ALS4MmMod32 SETX function | 1. GO:0048853 ~ forebrain morphogenesis |
| 2. GO:0007517 ~ muscle organ development | |
| 3. GO:0007399 ~ nervous system development | |
| 4. GO:0010468 ~ regulation of gene expression | |
| 5. GO:0051254 ~ positive regulation of RNA metabolic process | |
| ALS4HsMod77 overall | 1. GO:0015031 ~ protein transport |
| 2. GO:0043067 ~ regulation of programmed cell death | |
| 3. GO:0034308 ~ primary alcohol metabolic process | |
| 4. GO:0008299 ~ isoprenoid biosynthetic process | |
| 5. GO:0051046 ~ regulation of secretion | |
| ALS4HsMod77 SETX function | 1. GO:0050804 ~ modulation of synaptic transmission |
| 2. GO:0006915 ~ apoptotic process | |
| 3. GO:0006887 ~ exocytosis | |
| 4. GO:0045773 ~ positive regulation of axon extension | |
| 5. GO:0050684 ~ regulation of mRNA processing |