Fig. 3.

Repertoire of somatic alterations in coding regions of CP samples. (a) Age, gender, histological type (up) and somatic alterations in coding regions identified in 26 CPs subjected to WGS. The effects of the somatic alterations are color-coded according to the legend. Alterations that occurred in the same gene at least in two samples and/or listed in COSMIC Cancer Gene Census were shown. (b) Schematics for CTNNB1 indicating the location of the identified mutations, the mutation marked red was the novel mutation identified in CP111, and the mutation marked green were the mutations not identified in ref. [31]. (c) FISH images of FBXW7 shown for CP12 (FBXW7-WT) and CP33 (FBXW7 W425X), scale bars: 50 μm