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. 2021 Dec 18;20:167. doi: 10.1186/s12943-021-01474-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Clinical significance of circIL4R in CRC tissues and serum. a FISH staining assay showed that circIL4R expression in CRC tissues was higher than that in the corresponding ANTs (200×). b-d qRT-PCR analysis showed that circIL4R expression was significantly upregulated in 120 CRC tissues compared with paired ANTs. e Changes in the levels of serum circIL4R in 50 newly diagnosed CRC patients before and after surgery were detected by qRT-PCR. f Relative levels of serum circIL4R in healthy controls (n = 40) and CRC patients (n = 40) were determined by qRT-PCR. g ROC curves were used to determine the diagnostic value of serum circIL4R either alone or in combination with CEA in CRC. h-k circIL4R expression was evaluated in different groups stratified according to clinical characteristics (pathological stage, M classification, N classification, T classification.) by violin plot. l and m Kaplan–Meier survival curves showed that CRC patients with high circIL4R expression exhibited shorter OS (n = 120, P = 0.0018) and DFS (n = 120, P = 0.0077) based on 120 clinical specimens. *P < 0.05, **P < 0.01, ***P < 0.001