Skip to main content
. 2021 Dec 18;16:83. doi: 10.1186/s13024-021-00501-z

Fig. 2.

Fig. 2

Hypothetical scheme of Lewy body formation in neurons. α-Synuclein exists in equilibrium between monomers and tetramers in the cytoplasm. Under pathologic conditions, the tetramer-monomer ratio decreases, and monomers bind to vesicle membranes. On the surface of membrane, α-synuclein tend to oligomerize, and toxic oligomers can disrupt lipid membranes. Monomers and oligomers form insoluble fibrils in the cytoplasm. Disrupted membranes, organelles, α-synuclein oligomers and fibrils are involved in the Lewy body formation