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Macroscopic findings of multiple system atrophy (MSA). The brains from MSA (A, C, E, and G) and control (B, D, F, and H) cases. The pons and cerebellar white matter are atrophic in MSA (A). Loss of neuromelanin pigment in the locus coeruleus (C) and substantia nigra (E) is observed in MSA. The discoloration and atrophy of the lateral putamen in MSA (G). Abbreviations: CWM, cerebellar white matter; LC, locus coeruleus; SN, substantia nigra
