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The cryo-EM structures of recombinant α-synuclein fibrils. A Two polymorphs of filaments from wild type fibrils: rod (Protein Data Bank [PDB] ID: 6CU7) and twister (PDB ID: 6CU8). B E46K mutant fibrils (PDB ID: 6L43). C H50Q mutant fibrils (PDB ID: 6PES). D A53T mutant fibrils (PDB ID: 6LRQ). Dotted boxes indicate the inter-protofilament interfaces of each α-synuclein fibril
