Table 3.
Studies on α-synuclein RT-QuIC using peripheral tissue samples
| Author | Tissue | Autopsy | Disease | N | N Control | Sensitivity | Specificity |
|---|---|---|---|---|---|---|---|
| De Luca [250] | OM | No | PD | 18 | 18 | 56% | 83% |
| MSA | 11 | 18 | 82% | 83% | |||
| Manne [251] | SMG | Yes | PD | 13 | 16 | 100% | 94% |
| ILBD | 3 | 16 | 100% | 94% | |||
| Wang [252] | Abdominal skin | Yes | PD | 47 | 73 | 94% | 93% |
| Lewy body dementia | 7 | 73 | 100% | 93% | |||
| MSA | 3 | 73 | 67% | 93% | |||
| Biopsy skin *1 | No | PD | 20 | 21 | 95% | 100% | |
| Manne [253] | Frozen skin *2 | Yes | PD | 25 | 25 | 96% | 96% |
| FFPE skin *2 | PD | 12 | 12 | 75% | 83% | ||
| Mammana [254] | Skin *3 | Yes | PD/DLB | 2 | 40 | 100% | 98% |
| ILBD | 7 | 40 | 86% | 98% | |||
| No | DLB | 15 | 41 | 100% | 95% | ||
| PD | 13 | 41 | 77% | 95% | |||
| Stefani [255] | OM | No | IRBD | 63 | 59 | 44% | 90% |
| PD | 41 | 59 | 46% | 90% | |||
| Perra [249] | OM | No | DLB | 43 | 38 | 81% | 92% |
*1 Biopsy skin samples are obtained from the leg or posterior cervical region. *2 The scalp skin is collected from the posterior lower occipital region along the midline. *3 Skin punches are collected from the cervical region and/or thigh. Abbreviations: FFPE Formalin-fixed paraffin-embedded, ILBD Incidental Lewy body disease, IRBD Isolated rapid eye movement sleep behavior disorder, MSA Multiple system atrophy, PD Parkinson’s disease, OM Olfactory mucosa, SMG Submandibular glands