Figure 6.

Immunohistochemistry of SMI-312(+) axon bundles, IBA1(+) microglia, and ED1(+) extrinsic macrophages in naïve (left), vehicle-treated (middle), and 11C7mAb-treated (right) optic nerve cross-sections. Results from groups 9 (top) and 10 (bottom) show a large inflammatory response and dropout of axons 30 days after induction in the vehicle-treated eyes, but with what appears to be much less inflammation and more axon preservation in eyes treated with 11C7mAb. Note that many of the microglia in the group 10, 11C7mAb eye appear to be ramified (resting).