. Author manuscript; available in PMC: 2021 Dec 18.

Published in final edited form as: Mol Genet Metab. 2021 Jan 13;132(2):119–127. doi: 10.1016/j.ymgme.2021.01.001

Table 2.

The least squares (LS) mean estimates of the long-term change in FSIQ score from baseline using a repeated measures model.

Analysis visit	N	LS mean change (SE)	95% CI
Analysis visit	N	LS mean change (SE)	Lower	Upper
Month 12	59	1.24 (2.155)	−3.05	5.52
Month 24	58	1.44 (2.174)	−2.89	5.76
Month 36	55	1.40 (2.183)	−2.94	5.74
Month 48	48	1.41 (2.238)	−3.04	5.85
Month 60	38	−1.62 (2.289)	−6.16	2.92
Month 72	23	0.21 (2.439)	−4.62	5.04
Month 84	27	1.14 (2.358)	−3.53	5.82

Baseline is defined as the first available measurement after determination of sapropterin responsiveness.

CI: confidence interval; FSIQ: full-scale intelligence quotient; LS: least squares; N: number of patients with data available; SE: standard error.