Table 3.
Adjusted means of HDL metrics by E2 and FSH tertiles in women traversing menopause
| Study outcomes | E2 tertilesa | FSH tertilesa | ||
|---|---|---|---|---|
| Adjusted mean (95% CI)b | Trend P value | Adjusted mean (95% CI)b | Trend P value | |
| HDL-C, mg/dL | 0.017 | 0.37 | ||
| Low | 59.9 (58.4, 61.4) | 60.6 (59.1, 62.1) | ||
| Medium | 60.4 (60.0, 62.9) | 60.2 (58.7, 61.6) | ||
| High | 61.4 (60.0, 62.9)c | 61.3 (59.6, 62.9) | ||
| ApoA-I, mg/dL | 0.57 | 0.046 | ||
| Low | 163.8 (160.7, 166.9) | 161.9 (158.8, 165.1) | ||
| Medium | 162.3 (159.3, 165.2) | 162.0 (158.9, 165.1) | ||
| High | 162.9 (159.9, 165.9) | 166.0 (162.4, 169.6) | ||
| Total HDL-P, μmol/L | 0.16 | 0.0005 | ||
| Low | 35.3 (34.7, 36.0) | 34.6 (33.9, 35.3) | ||
| Medium | 35.1 (34.5, 35.7) | 35.0 (34.3, 35.6) | ||
| High | 34.9 (34.2, 35.5) | 36.1 (35.3, 36.9)c | ||
| Large HDL-P, μmol/L | <0.0001 | 0.017 | ||
| Low | 8.3 (8.0, 8.7) | 9.2 (8.8, 9.5) | ||
| Medium | 8.6 (8.3, 9.0) | 8.4 (8.0, 8.8)c | ||
| High | 9.3 (8.9, 9.7)c | 8.6 (8.1, 9.0)c | ||
| Medium HDL-P, μmol/L | 0.034 | 0.0097 | ||
| Low | 11.4 (10.8, 12.1) | 10.2 (9.5, 10.9) | ||
| Medium | 10.9 (10.3, 11.6) | 11.5 (10.8, 12.1)c | ||
| High | 10.6 (9.9, 11.3)c | 11.6 (10.8, 12.4)c | ||
| Small HDL-P, μmol/L | 0.23 | 0.50 | ||
| Low | 15.5 (14.7, 16.3) | 15.3 (14.6, 16.1) | ||
| Medium | 15.6 (14.8, 16.3) | 15.1 (14.4, 15.9) | ||
| High | 15.0 (14.3, 15.8) | 15.7 (14.8, 16.5) | ||
| HDL size, nm | <0.0001 | 0.0003 | ||
| Low | 9.48 (9.42, 9.53) | 9.59 (9.53, 9.64) | ||
| Medium | 9.50 (9.45, 9.56) | 9.51 (9.45, 9.57)c | ||
| High | 9.62 (9.56, 9.67)c | 9.47 (9.41, 9.53)c | ||
| HDL-PL, mg/dL | 0.41 | 0.20 | ||
| Low | 54.4 (53.3, 55.5) | 54.4 (53.3, 55.5) | ||
| Medium | 54.2 (53.1, 55.2) | 54.1 (53.0, 55.2) | ||
| High | 54.8 (53.8, 55.9) | 55.2 (53.9, 56.4) | ||
| HDL-Tg, mg/dL | <0.0001 | 0.078 | ||
| Low | 17.7 (17.1, 18.4) | 18.9 (18.2, 19.5) | ||
| Medium | 18.3 (17.7, 18.9) | 18.2 (17.5, 18.8) | ||
| High | 19.2 (18.5, 19.8)c | 18.0 (17.3, 18.8) | ||
| HDL-CEC, % | 0.010 | 0.39 | ||
| Low | 3.91 (3.85, 3.98) | 3.95 (3.88, 4.02) | ||
| Medium | 3.95 (3.88, 4.02) | 3.94 (3.87, 4.01) | ||
| High | 4.00 (3.93, 4.07)c | 3.99 (3.91, 4.07) | ||
| HDL-CEC/Total HDL-P | 0.001 | 0.016 | ||
| Low | 0.113 (0.110, 0.115) | 0.116 (0.114, 0.119) | ||
| Medium | 0.115 (0.113, 0.117) | 0.115 (0.113, 0.117) | ||
| High | 0.117 (0.115, 0.119)c | 0.113 (0.110, 0.115)c | ||
Abbreviations: ApoB, apolipoprotein B; E2, estradiol; FSH, follicle-stimulating hormone; HDL-C, high-density lipoprotein cholesterol; HDL-CEC, HDL cholesterol efflux capacity; HDL-P, HDL particles; HDL-PL, HDL-phospholipid; HDL-Tg, HDL-triglyceride.
a E2 Tertiles: Low: E2 ≤ 17.47 pg/dL; Medium: 17.47 pg/dL < E2 ≤ 33.35 pg/dL; High: E2 > 33.35 pg/dL; FSH Tertiles: Low: FSH ≤ 44.7 mIU/mL; Medium:44.7 mIU/mL < FSH ≤ 93.9 mIU/mL; High: FSH > 93.9 mIU/mL
b Models adjusted for race, time-varying age and cycle day of blood draw + time-varying log-hsCRP, and BMI
c Significantly different from Low