Figure 6.

T cell receptor profiling reveals that rs61839660 minor allele homozygote Crohn’s disease patients may have a reduced capacity to mount a regulatory T cell response. [a] CDR3 region J and V segment entropy for CD4⁺ effector T cells [T_eff, empty circles] and regulatory T cells [T_reg, filled circles] among the genotypes. [b] Fractions of unique J segment clonotypes used by each genotype. [c] TT patient CD4⁺ T cells (T_reg and T_eff /conventional [T_conv] cells) preferentially use two TRBJ segments [TRBJ2-1 and TRBJ2-7]. T_reg and T_eff/T_conv from the same patient are denoted by conjoined lines and matching individual symbols. [d] Principal component analysis of J segment usage revealed distinct clustering by genotype.[ e] Heatmap for clustering of shared clonotypes matched by Hamming distance. [f]: TCR diversity ratio for T_reg/T_eff, measured by Gini index. TCR, T cell receptor.