Table 2.
Association between plasma kisspeptin and hypertensive disorders of pregnancy
| Crude | Adjusted | |||
|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | |
| Plasma kisspeptin (nmol/L) | 1.12 (1.04-1.20) | 0.004 | 1.30 (1.16-1.47) | <0.0001 |
| Gestational age (weeks) | 1.00 (0.98-1.02) | 0.972 | 0.95 (0.92-0.98) | 0.003 |
| Maternal age (years) | 1.04 (1.01-1.8) | 0.018 | 1.03 (0.99-1.08) | 0.089 |
|
Maternal ethnicity
(vs Caucasian) |
||||
| Afro-Caribbean | 1.70 (1.06-2.71) | 0.027 | 1.28 (0.75-2.18) | 0.374 |
| Asian | 1.23 (0.72-2.12) | 0.452 | 0.82 (0.46-1.45) | 0.493 |
| Other | 0.59 (0.25-1.40) | 0.232 | 0.51 (0.21-1.24) | 0.139 |
| Maternal BMI (kg/m 2 ) | 1.11 (0.08-1.15) | <0.0001 | 1.14 (1.10-1.18) | <0.0001 |
| Cigarette smoker | 1.00 (0.99-1.00) | 0.215 | 0.99 (0.99-1.00) | 0.121 |
| Parity | 0.96 (0.79-1.18) | 0.721 | 0.78 (0.63-0.97) | 0.025 |
Logistic regression was used to assess the association between (1) kisspeptin with HDP diagnosis in univariable analysis and (2) after adjustment for gestational age (estimated using CRL), maternal age, ethnicity, BMI, smoking status, and parity. Odds ratios denote odds of HDP diagnosis for every 1 nmol/L increase in plasma kisspeptin. A P value of < 0.05 was classified as significant. Bold numbers indicate statistically significant predictors of HDP after adjustment.
Abbreviations: BMI; body mass index; CRL, crown-rump length; HDP, hypertensive disorders of pregnancy; OR, odds ratio.