Table 3.
Selected models for the prediction of birthweight
| Models | Difference in birthweight (SDS) (95% CI) | Adjusted R2 (%) | SD of the residuals |
|---|---|---|---|
| BMI modela | |||
| Prepregnancy BMI | 0.03 (0.00; 0.05) | 6.1 | 0.93 |
| Biomarker modelb | |||
| Prepregnancy BMI | 0.02 (0.00; 0.04) | 6.2 | 0.93 |
| Glucose | 0.06 (-0.01; 0.14) | ||
| Triglycerides | 0.01 (-0.07; 0.05) | ||
| HDL-cholesterol | -0.03 (-0.11; 0.05) | ||
| Metabolite modelc | |||
| Prepregnancy BMI | 0.05 (0.03; 0.07) | 12.9 | 0.90 |
| Gln | 0.03 (-0.05; 0.13) | ||
| Lys | -0.04 (-0.12; 0.04) | ||
| NEFA.18:2 | 0.08 (-0.04; 0.19) | ||
| NEFA.20:3 | 0.06 (-0.06; 0.18) | ||
| NEFA.22:3 | -0.15 (-0.26; -0.05) | ||
| PC.aa.C30:0 | 0.05 (-0.04; 0.15) | ||
| PC.aa.C38:3 | 0.14 (0.00; 0.27) | ||
| PC.ae.C34:4 | -0.14 (-0.24; -0.05) | ||
| Lyso.PC.a.C16:1 | -0.23 (-0.33; -0.12) | ||
| Lyso.PC.a.C20:4 | 0.04 (-0.07; 0.14) | ||
| SM.a.C36:1 | -0.05 (-0.22; 0.12) | ||
| SM.a.C36:2 | -0.15 (-0.34; 0.04) | ||
| SM.a.C40:2 | 0.13 (0.01; 0.25) | ||
| SM.a.C42:4 | 0.12 (-0.01; 0.26) | ||
| Carn.a.C10:1 | -0.09 (-0.18; 0.00) | ||
| Asn/Asp ratio | 0.03 (-0.05; 0.11) | ||
| Gln/Glu ratio | 0.03 (-0.06; 0.12) | ||
| NEFA.16:1/16:0 ratio | -0.06 (-0.13; 0.01) | ||
| ΣPC.aa/ΣPC.ae ratio | -0.01 (-0.10; 0.07) |
Values represent regression coefficients (95% CI) and adjusted R2 obtained from linear regression models.
Abbreviations: Asn/Asp, asparagine/aspartic acid; BMI, body mass index; Gln/Glu, glutamine/glutamic acid; HDL, high-density lipoprotein; SDS, SD score.
aBMI model includes maternal prepregnancy BMI, gestational age at blood sampling, age, educational level, parity, smoking, alcohol consumption, folic acid supplementation, daily total energy intake, systolic blood pressure, and fetal sex.
bBiomarker model includes the BMI model with additional adjustment for maternal glucose, triglycideride, and HDL-cholesterol concentrations
cMetabolite model includes the BMI model with additional adjustment for selected maternal early-pregnancy metabolites.