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GlcCer and epidermal functions. Lamellar bodies after fusion with the apical plasma membrane of the uppermost granular cells release GlcCer into the intercellular spaces by exocytosis. There, GlcCer is hydrolyzed and the released ceramide becomes a part of stratum corneum consisting of dead keratinocytes embedded with extracellular lipids such as cholesterol, ceramides and fatty acids.
