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. 2021 Aug 13;107(1):e328–e347. doi: 10.1210/clinem/dgab602

Figure 4.

Figure 4.

Effects of 1 week treatment with difelikefalin on LH pulsatility and body temperature in OVX mice. OVX mice were implanted with osmotic minipumps delivering target 10 nM, 30 nM, or 100 nM steady-state plasma concentrations of difelikefalin for a week (n = 5/group). (A) Depicts 2 representative samples of LH and body temperature (Tb) from each treatment group (n = 5/group). (B) Baseline LH release during 180 minutes, F (3, 15) = 2.061, P = 0.1486. (C) Peak of LH pulses observed during 180 minutes, F (3, 16) = 1.992, P = 0.1558. (D) Number of LH pulses in 180 minutes, F (3, 16) = 0.8015, P = 0.5111. One-way ANOVA followed by Fisher’s post hoc test. *P < 0.05.