Figure 1.

Schematic of the peptides designed for this study and peptide conjugation strategy. Both peptides were designed with an azide group for azide-alkyne click functionalization to the PdBT crosslinker that has an alkyne group on the backbone and a fluorophore for tracking release. The MMP-HAV peptide was designed with an MMP-sensitive sequence to study if release could be enzymatically controlled. Each peptide can be conjugated to the PdBT crosslinker via azide-alkyne click chemistry. The alkyne backbone pieces on the PdBT macromers are represented by the purple pentagons