Table 3.
Upregulated glycoproteins in the serum of the AD group (identified proteins from the UniProt Homo sapiens database).
| Protein ID | Protein name | Mass | Glycosylation | Posttranslational modification |
|---|---|---|---|---|
| Q9UP79 | A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAM-TS 8) (ADAM-TS8) (ADAMTS-8) (EC 3.4.24.-) (METH-2) (METH-8) | 96,460 | N-linked (GlcNAc) asparagine | PTM: the precursor is cleaved by a furin endopeptidase |
| B7ZC32 | Kinesin-like protein KIF28P (kinesin-like protein 6) | 108,254 | ||
| Q9Y3C8 | Ubiquitin-fold modifier-conjugating enzyme 1 (Ufm1-conjugating enzyme 1) | 19,458 | ||
| P00742 | Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor) (cleaved into factor X light chain, factor X heavy chain, and activated factor Xa heavy chain) | 54,732 | O-linked (GalNAc) threonine | PTM: the vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind to calcium |
| P20340 | Ras-related protein Rab-6A (Rab-6) | 23,593 | PTM: prenylated | |
| Q9NRR8 | CDC42 small effector protein 1 (CDC42-binding protein SCIP1) (small effector of CDC42 protein 1) | 8,925 | ||
| Q9NYH9 | U3 small nucleolar RNA-associated protein 6 homolog (hepatocellular carcinoma-associated antigen 66) (multiple hat domain protein) | 70,194 | ||
| P18077 | 60S ribosomal protein L35a (cell growth-inhibiting gene 33 protein) (large ribosomal subunit protein eL33) | 12,538 | ||
| Q3SXY7 | Leucine-rich repeat, immunoglobulin-like domain, and transmembrane domain-containing protein 3 | 74,754 | N-linked (GlcNAc) asparagine | PTM: glycosylated |
| Q9NUL5 | Shiftless antiviral inhibitor of ribosomal frameshifting protein (SFL) (SHFL) (interferon-regulated antiviral protein) (IRAV) (repressor of yield of DENV protein) (RyDEN) | 33,110 | ||
| Q12788 | Transducin beta-like protein 3 (WD repeat-containing protein SAZD) | 89,035 | ||
| O94854 | Uncharacterized protein KIAA0754 | 135,148 | ||
| Q9BXJ7 | Protein amnionless (cleaved into soluble protein amnionless) | 47,754 | N-linked (GlcNAc) asparagine | PTM: N-glycosylated |
| Q09019 | Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (protein 59) (protein DMR-N9) | 70,438 | ||
| Q02846 | Retinal guanylyl cyclase 1 (RETGC-1) (EC 4.6.1.2) (CG-E) (guanylate cyclase 2D, retinal) (rod outer segment membrane guanylate cyclase) (ROS-GC) | 120,059 | N-linked (GlcNAc) asparagine | |
| Q3LHN2 | Keratin-associated protein 19-2 | 5,737 | ||
| O95925 | Eppin (cancer/testis antigen 71) (CT71) (epididymal protease inhibitor) (protease inhibitor WAP7) (serine protease inhibitor-like with Kunitz and WAP domain 1) (WAP four-disulfide core domain protein 7) | 15,284 | ||
| Q9NYW3 | Taste receptor type 2 member 7 (T2R7) (taste receptor family B member 4) (TRB4) | 36,550 | N-linked (GlcNAc) asparagine | |
| Q6UWV2 | Myelin protein zero-like protein 3 | 25,989 | N-linked (GlcNAc) asparagine | |
| Q9Y5X4 | Photoreceptor-specific nuclear receptor (nuclear receptor subfamily 2 group E member 3) (retina-specific nuclear receptor) | 44,692 | ||
| Q6Y288 | Beta-1,3-glucosyltransferase (Beta3Glc-T) (EC 2.4.1.-) (beta 3-glucosyltransferase) (beta-3-glycosyltransferase-like) | 56,564 | N-linked (GlcNAc) asparagine | |
| Q8TB45 | DEP domain-containing mTOR-interacting protein (DEP domain-containing protein 6) | 46,294 | PTM: phosphorylated. Phosphorylation weakens interaction with MTOR within mTORC1 and mTORC2 | |
| Q9UPG8 | Zinc finger protein PLAGL2 (pleiomorphic adenoma-like protein 2) | 54,584 | ||
| Q9HCG1 | Zinc finger protein 160 (zinc finger protein HZF5) (zinc finger protein Kr18) (HKr18) | 94,112 | ||
| P30281 | G1/S-specific cyclin-D3 | 32,520 | PTM: polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation | |
| A0A286YF01 | Small cysteine and glycine repeat-containing protein 7 (keratin-associated protein 28-7) | 8,951 | ||
| O15539 | Regulator of G protein signaling 5 (RGS5) | 20,946 | ||
| Q12979 | Active breakpoint cluster region-related protein | 97,598 | ||
| Q96EN8 | Molybdenum cofactor sulfurase (MCS) (MOS) (MoCo sulfurase) (hMCS) (EC 2.8.1.9) (molybdenum cofactor sulfurtransferase) | 98,120 | ||
| P13765 | HLA class II histocompatibility antigen, DO beta chain (MHC class II antigen DOB) | 30,822 | N-linked (GlcNAc asparagine | |
| Q6L8H2 | Keratin-associated protein 5-3 (keratin-associated protein 5-9) (keratin-associated protein 5.3) (keratin-associated protein 5.9) (UHS KerB-like) (ultrahigh sulfur keratin-associated protein 5.3) | 22,106 | ||
| P21941 | Cartilage matrix protein (Matrilin-1) | 53,701 | N-linked (GlcNAc) asparagine | |
| Q6IFN5 | Olfactory receptor 7E24 (olfactory receptor OR19-14) | 38,279 | N-linked (GlcNAc) asparagine | |
| Q96BH3 | Epididymal sperm-binding protein 1 (epididymal secretory protein 12) (hE12) | 26,106 | N-linked (GlcNAc) asparagine | PTM: N-glycosylated |
| O95149 | Snurportin-1 (RNA U transporter 1) | 41,143 | ||
| Q9BSJ5 | Uncharacterized protein C17orf80 (cell migration-inducing gene 3 protein) (human lung cancer oncogene 8 protein) (HLC-8) | 67,315 | ||
| Q9H1E5 | Thioredoxin-related transmembrane protein 4 (thioredoxin domain-containing protein 13) | 38,952 | ||
| Q8NCL4 | Polypeptide N-acetylgalactosaminyltransferase 6 (EC 2.4.1.41) (polypeptide GalNAc transferase 6) (GalNAc-T6) (pp-GaNTase 6) (protein-UDP acetylgalactosaminyltransferase 6) (UDP-GalNAc:polypeptide N-acetylgalacto saminyltransferase 6) | 71,159 | N-linked (GlcNAc) asparagine | |
| Q4G112 | Heat shock factor protein 5 (HSF 5) (heat shock transcription factor 5) (HSTF 5) | 65,278 | ||
| Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 (liver-specific organic anion transporter 1) (LST-1) (OATP-C) (sodium-independent organic anion-transporting polypeptide 2) (OATP-2) (solute carrier family 21 member 6) | 76,449 | N-linked (GlcNAc) asparagine | |
| P55073 | Thyroxine 5-deiodinase (EC 1.21.99.3) (5DIII) (DIOIII) (type 3 DI) (type III iodothyronine deiodinase) | 33,947 | ||
| Q9H694 | Protein bicaudal C homolog 1 (Bic-C) | 104,844 |