Table 4.
Downregulated glycoproteins in the serum of the AD group (identified proteins from the UniProt Homo sapiens database).
| Protein ID | Protein names | Mass | Glycosylation | Posttranslational modification |
|---|---|---|---|---|
| Q9UBG0 | C-type mannose receptor 2 (C-type lectin domain family 13 member E) (endocytic receptor 180) (macrophage mannose receptor 2) (urokinase-type plasminogen activator receptor-associated protein) (UPAR-associated protein) (urokinase receptor-associated protein) (CD antigen CD280) | 166,674 | N-linked (GlcNAc) (complex) asparagine | PTM: N-glycosylated |
| Q96CS3 | FAS-associated factor 2 (protein ETEA) (UBX domain-containing protein 3B) (UBX domain-containing protein 8) | 52,623 | ||
| Q9Y6E7 | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial (EC 2.3.1.-) (NAD-dependent ADP-ribosyltransferase sirtuin-4) (EC 2.4.2.-) (NAD-dependent protein deacetylase sirtuin-4) (EC 2.3.1.286) (regulatory protein SIR2 homolog 4) (SIR2-like protein 4) | 35,188 | ||
| Q8N6S4 | Ankyrin repeat domain-containing protein 13C | 60,818 | ||
| Q9UHR4 | Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1) (insulin receptor tyrosine kinase substrate) | 56,883 | PTM: Phosphorylated on tyrosine in response to insulin | |
| B2RUY7 | von Willebrand factor C domain-containing protein 2-like (Brorin-like) | 24,570 | ||
| Q9Y3F4 | Serine-threonine kinase receptor-associated protein (MAP activator with WD repeats) (UNR-interacting protein) (WD-40 repeat protein PT-WD) | 38,438 | ||
| Q8TCV5 | WAP four-disulfide core domain protein 5 (putative protease inhibitor WAP1) (p53-responsive gene 5 protein) | 24,238 | ||
| O60568 | Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (including procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (lysyl hydroxylase 3) (LH3); procollagen glycosyltransferase (EC 2.4.1.50) (EC 2.4.1.66) (galactosylhydroxylysine-glucosyltransferase) (procollagen galactosyltransferase) | 84,785 | N-linked (GlcNAc) asparagine | |
| Q7Z7J5 | Developmental pluripotency-associated protein 2 (pluripotent embryonic stem cell-related gene 1 protein) | 33,784 | ||
| Q8N6C5 | Immunoglobulin superfamily member 1 (IgSF1) (immunoglobulin-like domain-containing protein 1) (inhibin-binding protein) (InhBP) (pituitary gland-specific factor 2) (p120) | 148,936 | N-linked (GlcNAc) asparagine | |
| Q04837 | Single-stranded DNA-binding protein, mitochondrial (Mt-SSB) (MtSSB) (PWP1-interacting protein 17) | 17,260 | ||
| Q7RTX1 | Taste receptor type 1 member 1 (G protein-coupled receptor 70) | 93,074 | N-linked (GlcNAc) asparagine | |
| P13994 | Coiled-coil domain-containing protein 130 (9 kDa protein) | 44,802 | ||
| Q5T440 | Putative transferase CAF17, mitochondrial (EC 2.1.-.-) (iron-sulfur cluster assembly factor homolog) | 38,155 | ||
| A7E2S9 | Putative ankyrin repeat domain-containing protein 30B-like | 28,549 | ||
| Q6QNK2 | Adhesion G protein-coupled receptor D1 (G protein-coupled receptor 133) (G protein-coupled receptor PGR25) | 96,530 | N-linked (GlcNAc) asparagine | |
| Q8NBR0 | Tumor protein p53-inducible protein 13 (damage-stimulated cytoplasmic protein 1) | 42,238 | ||
| A2VDJ0 | Transmembrane protein 131-like | 179,339 | N-linked (GlcNAc) asparagine | |
| Q9NZT2 | Opioid growth factor receptor (OGFr) (protein 7-60) (zeta-type opioid receptor) | 73,325 | ||
| P62910 | 60S ribosomal protein L32 (large ribosomal subunit protein eL32) | 15,860 | ||
| Q8WXI2 | Connector enhancer of kinase suppressor of ras 2 (connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2) | 117,535 | PTM: phosphorylated on tyrosine | |
| O95396 | Adenylyltransferase and sulfurtransferase MOCS3 (molybdenum cofactor synthesis protein 3) (molybdopterin synthase sulfurylase) (MPT synthase sulfurylase) (including molybdopterin-synthase adenylyltransferase (EC 2.7.7.80) (adenylyltransferase MOCS3) (sulfur carrier protein MOCS2A adenylyltransferase); molybdopterin-synthase sulfurtransferase (EC 2.8.1.11) (sulfur carrier protein MOCS2A sulfurtransferase) (sulfurtransferase MOCS3)) | 49,669 | ||
| Q8IVN8 | Somatomedin-B and thrombospondin type-1 domain-containing protein (RPE-spondin) | 29,610 | N-linked (GlcNAc) asparagine | |
| P55055 | Oxysterol receptor LXR-beta (liver X receptor beta) (nuclear receptor NER) (nuclear receptor subfamily 1 group H member 2) (ubiquitously expressed nuclear receptor) | 50,974 | PTM: sumoylated by SUMO2 at Lys-409 and Lys-447 during the hepatic acute phase response | |
| Q7Z3I7 | Zinc finger protein 572 | 61,238 | ||
| Q9Y580 | RNA-binding protein 7 (RNA-binding motif protein 7) | 30,504 | PTM: phosphorylated at Ser-136 by MAPK14/p38-alpha-activated MAPKAPK2/MK2 | |
| P48729 | Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1) | 38,915 | ||
| P19532 | Transcription factor E3 (class E basic helix-loop-helix protein 33) (bHLHe33) | 61,521 | PTM: phosphorylation by MTOR regulates its subcellular location and activity | |
| Q8WXH4 | Ankyrin repeat and SOCS box protein 11 (ASB-11) | 35,367 | ||
| Q86U42 | Polyadenylate-binding protein 2 (PABP-2) (poly(A)-binding protein 2) (nuclear poly(A)-binding protein 1) (poly(A)-binding protein II) (PABII) (polyadenylate-binding nuclear protein 1) | 32,749 | PTM: arginine dimethylation is asymmetric and involves PRMT1 and PRMT3 | |
| Q96MT1 | RING finger protein 145 (EC 2.3.2.27) | 75,617 | ||
| P17643 | 5,6-Dihydroxyindole-2-carboxylic acid oxidase (DHICA oxidase) (EC 1.14.18.-) (catalase B) (glycoprotein 75) (melanoma antigen gp75) (tyrosinase-related protein 1) (TRP) (TRP-1) (TRP1) | 60,724 | N-linked (GlcNAc) asparagine | PTM: glycosylated |
| Q9NW75 | G patch domain-containing protein 2 | 58,944 | ||
| Q09472 | Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (histone butyryltransferase p300) (EC 2.3.1.-) (histone crotonyltransferase p300) (EC 2.3.1.-) (protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (protein lactyltransferase p300) (EC 2.3.1.-) (protein propionyltransferase p300) (EC 2.3.1.-) | 264,161 | PTM: acetylated on Lys at up to 17 positions by intermolecular autocatalysis | |
| P58173 | Olfactory receptor 2B6 (Hs6M1-32) (olfactory receptor 2B1) (olfactory receptor 2B5) (olfactory receptor 5-40) (OR5-40) (olfactory receptor 6-31) (OR6-31) (olfactory receptor OR6-4) | 35,414 | N-linked (GlcNAc) asparagine | |
| Q15776 | Zinc finger protein with KRAB and SCAN domains 8 (LD5-1) (zinc finger protein 192) | 65,816 |