Table 3.

Drug solubility in different aqueous media (n=3, mean ± SD).

No.	Different pH values	Solubility (MQ/mL)
1	50 mM PBS pH 3.0	0.23±0.01
2	50 mM Acetate Buffer pH 4.0	0.32±0.04
3	50 mM PBS pH 6.0	0.23±0.01
4	50 mM PBS pH 7.4	0.27±0.04
5	50 mM Tris pH 9.0	0.35±0.07
6	Milli-Q Water	0.39±0.08
Different concentrations of SDS
7	0.1% SDS in pH 7.4 PBS	41.73±0.72
8	0.25% SDS in pH 7.4 PBS	102.22±4.92
9	0.5% SDS in pH 7.4 PBS	264.08±20.55
10	1% SDS in pH 7.4 PBS	545.98±4.12
Same concentration of excipient as in the RLD
11	0.3% Tween 80 in pH 7.4 PBS	6.34±0.45
12	2.88% PEG03350 in pH 7.4 PBS	0.63±0.01
13	0.5% PVP K-17PF in pH 7.4 PBS	0.33±0.02
In suspension formulations
14	RLD	10.01±0.26
15	F-A	7.19±0.11
16	F-B	10.79±0.04
17	F-C	7.53±0.03
19	F-D	10.04±0.04