Table 4.
Observed solubility of MPA in different organic solvents.
| Solvent | Solubility at room temperature mg/mL | Solubility at 50°C mg/mL |
|---|---|---|
|
| ||
| Methanol | < 18.09 | > 18.09 |
| Ethanol | < 20 | > 20 |
| Isopropanol | < 18.24 | > 18.24 |
| Acetone | > 25.03 | --* |
| Acetonitrile | < 25.05 | > 25.05 |
| Ethyl acetate | < 24.15 | > 24.15 |
| Tetrahydrofuran | > 34.97 | --* |
| Methanol/H2O (1/1) | < 10** | < 10 |
| Ethanol/H2O (1/1) | < 10** | < 10 |
| Acetone/H2O (1/1) | < 10** | < 10 |
*
Since the solubility at room temperature is sufficiently high, solubility at higher temperature (50°C) was not tested.