Table 1.

The main pharmacokinetic parameters of Taxotere® and FA-BSA-PEG/MoOx + DTX after intravenous administration

Parameters	Taxotere®	Nanosheet
AUC(0-t) (mg/L*h)	3.29 ± 0.24	10.68 ± 0.58***
AUC(0-∞) (mg/L*h)	4.13 ± 0.06	15.28 ± 1.66**
MRT(0-t) (h)	1.46 ± 0.14	7.38 ± 0.32***
MRT(0-∞) (h)	4.65 ± 0.83	31.01 ± 6.71*
t1/2z (h)	5.72 ± 0.78	35.06 ± 7.50*
CLz (L/h/kg)	2.42 ± 0.04	0.66 ± 0.08***
Cmax (mg/L)	8.37 ± 1.33	17.62 ± 2.06**

Asterisks (*) denote statistical significance of nanosheet vs. commercial Taxotere® (*p < 0.05, **p < 0.01, ***p < 0.001)