Table 6.
Summary of functional characterization of HCP5 in various cancers
| Cancers | Expression | Related genes | Role | References |
|---|---|---|---|---|
| Thyroid carcinoma | Upregulated | miR-22-3p, miR-186-5p, miR-216a-5p, ST6GAL2 | Oncogene | [14] |
| Anaplastic thyroid cancer | Upregulated | miR-128-3p | Oncogene | [10] |
| Bladder cancer | Upregulated | miR-29b-3p, HMGB1 | Oncogene | [28] |
| Breast cancer | Upregulated | miR-219a-5p, BIRC3 | Oncogene | [29] |
| TNBC | Upregulated | PTEN | Oncogene | [30] |
| Cervical cancer | Upregulated | miR-15a, MACC1 | Oncogene | [31] |
| ccRCC | Upregulated | miR-140-5p, IGF1R | Oncogene | [12] |
| Colon cancer | Upregulated | PI3K/AKT/AP1G1 | Oncogene | [32] |
| Colorectal cancer | Upregulated | miR-299-3p, PFN1/AKT | Oncogene | [33] |
| Colorectal cancer | Upregulated | miR-139-5p, ZEB1 | Oncogene | [13] |
| CSCC | Upregulated | miR-138-5p, EZH2 | Oncogene | [34] |
| ESCC | Upregulated |
miR-139-5p/PDE4A PI3K/AKT/mTOR |
Oncogene | [35] |
| Gastric cancer | Upregulated | miR-299-3p, SMAD5 | Oncogene | [36] |
| Gastric cancer | Upregulated | miR-186-5p, WNT5A | Oncogene | [9] |
| Gastric cancer | Upregulated | miR-519d, HMGA1 | Oncogene | [37] |
| Gastric cancer | Upregulated | miR-128, HMGA2 | Oncogene | [17] |
| Glioma | Upregulated | miR-139, RUNX1 | Oncogene | [42] |
| Glioma | Upregulated | miR-128 | Oncogene | [43] |
| Hepatocellular carcinoma | Upregulated | miR-29b-3p, DNMT3A | Oncogene | [11] |
| Large B-cell lymphoma | Upregulated | miR-27b-3p, MET | Oncogene | [44] |
| Lung adenocarcinoma | Upregulated | miR-203, SNAI | Oncogene | [45] |
| NSCLC | Upregulated | miR-320, Survivin | Oncogene | [18] |
| Multiple myeloma | Upregulated | miR-128-3p, PLAGL2 | Oncogene | [46] |
| Neuroblastoma | Upregulated | miR-186-5p, MAP3K2 | Oncogene | [47] |
| OSCC | Upregulated | miR-140-5p, SOX4 | Oncogene | [48] |
| Osteosarcoma | Upregulated | miR-101, EPHA7 | Oncogene | [20] |
| Ovarian cancer | Upregulated | miR-525-5p, PRC1 | Oncogene | [49] |
| Pancreatic cancer | Upregulated | miR-214-3p, HDGF | Oncogene | [8] |
| Pancreatic cancer | Upregulated | miR-140-5p, CDK8 | Oncogene | [38] |
| Prostate cancer | Upregulated | miR-4656, CEMIP | Oncogene | [50] |
| Renal cell carcinoma | Upregulated | miR-214-3p, MAPK1 | Oncogene | [19] |
| Retinoblastoma | Upregulated | miR-3619-5p, HDAC9 | Oncogene | [51] |
| Skin cutaneous melanoma | Downregulated | miR-12, RARRES3 | Suppressor | [15] |
TNBC triple-negative breast cancer, ccRCC clear cell renal cell carcinoma, CSCC cutaneous squamous cell carcinoma, ESCC esophageal squamous cell carcinoma, NSCLC non-small cell lung cancer cells, OSCC oral squamous cell carcinoma